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Furthermore, inhibitors of protein kinase R-like endoplasmic reticulum kinase (PERK), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) each attenuated renal fibroblast proliferation and collagen production, suggesting the mechanistic role for each in mediating the effect of TMAO on renal fibroblast proliferation

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Groups A13 were raised in the clean room of the out-of-compartment animal centre and treated under normoxic conditions

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